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Selected Publications

(To be edited)


Y He, RC Akumuo, Y Yang, SJ Hewett. Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity. Mar 2017. Neuroscience Letters 643, 65-69


SJ Hewett, J Shi, Y Gong, K Dhandapani, C Pilbeam, JA Hewett. Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1). Dec 2016. Journal of Biological Chemistry 291 (53), 27279-27288

J Shi, Y He, SJ Hewett, JA Hewett. Interleukin 1β Regulation of the System xc− Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR. Jan 2016. Journal of Biological Chemistry 291 (4), 1643-1651


Thorn TL, He Y, Jackman NA, Lobner D, Hewett JA, Hewett SJ. A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death. ASN Neuro. 2015 Nov 9;7(6). pii: 1759091415614301. doi: 10.1177/1759091415614301. Print 2015 Dec. PMID: 26553727

Ann Massie, Severine Boillee, Sandra Hewett, Lori Knackstedt and Jan Lewerenz. Main path and byways: non-vesicular glutamate release by system xc- as an important modifier of glutamatergic neurotransmission. Journal of Neurochemistry 2015 Accepted Article DOI: 10.1111/jnc.13348

Evonuk KS, Baker BJ, Doyle RE, Moseley CE, Sestero CM, Johnston BP, De Sarno P, Tang A, Gembitsky I, Hewett SJ, Weaver CT, Raman C, DeSilva TM. 
Inhibition of System Xc- Transporter Attenuates Autoimmune Inflammatory Demyelination. J Immunol. 2015 Jul 15;195(2):450-63. doi: 10.4049/jimmunol.1401108. Epub 2015 Jun 12.

He Y, Jackman NA, Thorn TL, Vought VE, Hewett SJ. (2015) Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-Dependent upregulation of glutathione synthesis. Glia. 2015 Apr 16. doi: 10.1002/glia.22828. [Epub ahead of print]


Jan Lewerenz, Sandra J. Hewett, Ying Huang, Maria Lambros, Peter W. Gout, Peter W. Kalivas, Ann Massie, Ilse Smolders, Axel Methner, Mathias Pergande, Sylvia B. Smith, Vadivel Ganapathy, and Pamela Maher. Antioxidants & Redox Signaling. February 10, 2013, 18(5): 522-555. doi:10.1089/ars.2011.4391.


Hewett JA, Hewett SJ. (2012) Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures. Methods Mol Biol. 814:251-63.

Uliasz TF, Hamby ME, Jackman NA, Hewett JA, Hewett SJ. (2012) Generation of primary astrocyte cultures devoid of contaminating microglia. Methods Mol Biol. 814:61-79.

Claycomb RJ, Hewett SJ, Hewett JA. (2012) Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2. Neurobiol Dis. 45(1):234-42.


Sen E, Basu A, Willing LB, Uliasz TF, Myrkalo JL, Vannucci SJ, Hewett SJ, Levison SW. (2011) Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro. 2011 Jul 26;3(3):e00062. doi: 10.1042/AN20100029.

Claycomb RJ, Hewett SJ, Hewett JA. (2011) Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. Epilepsia. 52(2):273-83.


Jackman NA, Uliasz TF, Hewett JA, Hewett SJ (2010) Regulation of System xc- Activity and Expression in Astrocytes by Interleukin-1b: Implications for Hypoxic Neuronal Injury. Glia. 2010 Jul 19. [Epub ahead of print] PMID: 20645408 [PubMed - as supplied by publisher]

Hamby ME, Hewett JA, Hewett SJ. (2010) Smad3-dependent signaling underlies the TGF-b1-mediated enhancement in astrocytic iNOS expression. Glia. 2010 Aug 15;58(11):1282-91. PMID: 20607716 [PubMed - in process]


Chi-un C, Lewerenz J, Fischer, G., Uliasz, T.F. Espey, M.G., Hummel, F. C, King, B., Schwedhelm, E., Böger, R.H., Gerloff, R. Hewett, S.J., Magnus, T., Donzelli, S. (2009) HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity. Journal of Neurochemistry 110: 1766-1773.


Hamby, M.E., Hewett, J.A. and Hewett, S. J. (2008) TGF-?1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner. Prostaglandins and other lipid mediators 85:115-124.

Hamby, M.E., Gragnolati, A.R., Hewett, S.J. and Hewett, J.A. (2008) TGF-β1 and TNFα potentiate astrocytic nitric oxide production by recruiting distinct sub-populations of astrocytes to express NOS-2. Neurochem. Int. 52: 962-971.

Taylor. A.L.,Bonventre, J.V., Hewett, J.A., Hewett, S.J. (2008) Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death Journal of Neurochemistry 106: 1828-1840.


Fogal, B. Li, J., Lobner, D., McCullough, L.D. and Hewett, S.J. (2007) System xc- activity and astrocytes are necessary for IL-1?-mediated hypoxic neuronal injury. Journal of Neuroscience 27: 10094-10105.