Selected Publications

For a complete list of publications, see PubMed
Google Scholar Profile


Dutta, S.S. Andonova, A.A., Wöllert, T. Hewett, S.J. and Hewett, J.A. (2022) P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in the maintenance of innate seizure threshold. Neurobiology of Disease 168: 105689  PMC9067394

He, Y and Hewett, S.J. (2022) The Cystine/Glutamate Antiporter, System xc, contributes to cortical infarction after moderate but not severe focal cerebral ischemia in mice, Frontiers in Neuroscience 16:821036 https://doi:10.3389/fncel.2022.821036   PMC9165760

Martinez-Lozada, S. J. Hewett, F. Zafra and A. Ortega Editorial: The known, the unknown, and the future of glutamate transporters Frontiers in Cellular Neuroscience 2022 Vol. 16 DOI: 10.3389/fncel.2022.1005834


Sears, S. M.S, Roberts, S.H. and Hewett, SJ. (2021) Hyperexcitability and Structural Sex Differences in Brain of Mice Lacking the Cystine/Glutamate Antiporter, System xc. Journal of Neuroscience Research 99(12)3339-3353  PMC6398109

Sears, S.M.S. and Hewett, S.J. (2021) Influence of Glutamate and GABA Transport on Brain Excitatory/Inhibitory Balance Experimental Biology and Medicine PMID: 33554649 DOI: 10.1177/1535370221989263.


Sosnoski, H.M, Sears, SMS, He, Y, Frare, C. and Hewett, S.J.  (2020) Sexually dimorphic and brain region-specific transporter adaptations in system xc− null mice Neurochemistry International 121: 104888   PMC7704737


Sears, S.M.S, Hewett, JA and Hewett, SJ (2019) Decreased epileptogenesis in mice lacking the System xc- transporter occurs in association with a reduction in AMPA receptor subunit GluA1 Epilepsia Open 2019;4:133–143.  PMC6398109


Kanzler, M.A., Van Dyke, A.M., He, Y., Hewett, J.A., Hewett, S.J. (2018) Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis. Epilepsia Open 3(2):255–263. doi:10.1002/epi4.12221 PMC5983117

Chowdhury, T. Allen, M.A., Thorn, T.A., He, Y. and Hewett, S.J. (2018) Interleukin-1β protects neurons against oxidant-induced injury via promotion of astrocyte glutathione production. Antioxidants 7(8), 100; doi:10.3390/antiox7080100. PMC6115796


Wilson, J. H., Criss, A. H., Spangler, S. A., Walukevich, K., & Hewett, S. (2017). Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study. Journal of Psychopharmacology, 31(10), 1374-1376.

Y He, RC Akumuo, Y Yang, SJ Hewett. Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity. Mar 2017. Neuroscience Letters 643, 65-69


SJ Hewett, J Shi, Y Gong, K Dhandapani, C Pilbeam, JA Hewett. Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1). Dec 2016. Journal of Biological Chemistry 291 (53), 27279-27288

J Shi, Y He, SJ Hewett, JA Hewett. Interleukin 1β Regulation of the System xc− Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR. Jan 2016. Journal of Biological Chemistry 291 (4), 1643-1651